- Phineas Flynn (Phineas and Ferb) as Mickey Mouse
- Mike Wazowski (Monsters, Inc.) as Donald Duck
- Ferb Fletcher (Phineas and Ferb) as Goofy
- Perry the Platypus (Phineas and Ferb) as Pluto
- Isabella Garcia-Shapiro (Phineas and Ferb) as Minnie Mouse
- Celia Mae (Monsters, Inc.) as Daisy Duck
- Vanessa Doofenshmirtz (Phineas and Ferb) as Clarabelle Cow
- Constantine (Muppets Most Wanted) as Captain Pete
- Chick Hicks (Cars), Randall Boggs (Monsters, Inc.), and Skinner (Ratatouille) as the Beagle Boys
- Clopin (The Hunchback of Notre Dame) as The Troubadour
- This is the real first time someone plays Mickey Mouse in a movie parody style on the Alec Thaggard Channel, as "Who Framed SpongeBob SquarePants" has Mickey play himself.
- Vincent Martella
- Billy Crystal
- Thomas Brodie-Sangster/David Errigo, Jr.
- Dee Bradley Baker
- Alyson Stoner
- Jennifer Tilly
- Olivia Olson
- Matt Vogel
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